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Degenerative Disc Disease wo pics

Degenerative Disc Disease wo pics - Nucleus pulposus...

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7/13/2010 1 Lia M. Nightingale, Ph.D. Nucleus pulposus contains: Collagen (20% of dry weight) Elastin 90% water Proteoglycans (mostly aggrecan) Annulus fibrosus contains: Water Collagen (70% of dry weight) Proteoglycans (mostly aggrecan) Podichetty. 2007. Cell Mol Biol . 53:4. a. Vitamin D b. Vitamin C c. Vitamin A d. Pantothenic acid a. Repeating disaccharide chain b. Protein core surrounded by repeating disaccharide chain c. Protein core surrounded by an oligosaccharide d. None of the above Disc cell degradation exceeds synthesis Begins in teenage years Prevalence is unknown due to lack of standardized definition Has a genetic component Battie et al. 2006. J Bone Joint Surg . 88:3. Causes back pain one of the largest factors affecting the physical health status of elderly patients. Podichetty. 2007. Cell Mol Biol . 53:4.
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7/13/2010 2 Age/ Trauma ↓H 2 O in nucleus (90% → 70%) Increased compression stress ↓Blood flow ↓O 2 & nutrients iNOS ↑•NO proteoglycan synthesis ↑disc cell
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