Lipids 122109 wo pics

Lipids 122109 wo pics - 1 LIPID CHEMISTRY CHS 5& 10 Lia...

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Unformatted text preview: 1 LIPID CHEMISTRY CHS. 5 & 10 Lia M. Nightingale, Ph.D. Lipids Fats Oils ROLES OF LIPIDS IN THE BODY Energy Insulation & protection Cell membrane integrity Steroid hormones & hormone-like compounds Fat-soluble vitamin absorption Lipids ENERGY Lipids provide ____________ kcal/g. Found in reduced form One pound of fat contains __________ kcal. In order to lose 1 pound/week, a patient must average a 500 kcal deficit per day (through diet & exercise). Conversely, if a patient wants to gain 1 pound/week, they must eat 500 kcal/day more than their energy expenditure. LIPIDCLASSES Lipids Simple lipids Fatty acids (FA) Triglycerides (TGs) Sterols & steroids Complex lipids Phospholipids Phosphate Glycolipids Carbs Something else attached to lipid FATTY ACIDS Hydrophobic CH 3 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 C CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 O- O Hydrophilic Notice the carboxylic acid is ionized at physiologic pH. Why would this be? Also called acyls 2 FATTY ACID (FA) CLASSIFICATION Fatty acids Number of carbons (chain length) Number of double bonds (saturation) FATTY ACIDS (FA) CHAIN LENGTH Short chain 4-6 C long Butyric acid Medium chain 8-12 C long Lauric acid Long chain 14-24 C long Palmitic acid, essential fatty acids FATTY ACIDS (FA) SATURATION Saturated (SFA) No double bonds Fats Monounsaturated (MUFA) 1 double bond Oils Polyunsaturated (PUFA) >1 double bond Oils FATTY ACIDS Saturated fatty acid (SFA) No double bonds Fats at room temperature CH 3 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 C CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 O- O FATTY ACIDS Monounsaturated fatty acid (MUFA) 1 double bond Generally oils at room T COO- There is a C at each kink Methyl FATTY ACIDS Polyunsaturated fatty acid (PUFA) >1 double bonds Oils at room T COO- 3 PUFA Notice double bonds have methyl group in between = methylene interrupted Allows a more flexible structure COO- Methylene interruption; conjugated bonds (single and double bonds alternate) Can rotate around the methylene in the middle to several conformations FA NOMENCLATURE ω Δ COO- There are 2 ways of numbering double bonds: Δ and ω (depending on which end you number from) 9 DELTA( Δ ) NOMENCLATURE Δ COO- 1. Chain length (number of carbons) 2. Colon 3. List the number of double bonds 4. Count from delta end 5. List first C in ALL double bonds 1 2 3 4 5 6 7 8 10 11 12 13 14 15 16 17 18 18 : 1 Δ 9 9 OMEGANOMENCLATURE COO- 18 17 16 15 14 13 12 11 8 7 6 5 4 3 2 1 1. Chain length (number of carbons) 2. Colon 3. List the number of double bonds 4. Count from omega end 5. List first C in FIRST double bonds 18 : 1 ω 9 ω 10 Often n replaces ω FA NOMENCLATURE COO- Delta numbering: _______________ Omega numbering: _______________ FA NOMENCLATURE COO- Delta numbering: _______________ Omega numbering: _______________ Double bonds are always 3 C apart!! 4 SHORTCUT From delta to omega: 1. Subtract the LAST bond number from the total C in chain....
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Lipids 122109 wo pics - 1 LIPID CHEMISTRY CHS 5& 10 Lia...

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