Oxidation AOX 010510 2 slide

Oxidation AOX 010510 2 slide - 1 O XIDATION & A...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 1 O XIDATION & A NTIOXIDANT C HEMISTRY (P G . 417-425) Lia M. Nightingale, Ph.D. R EDOX R EVIEW 1. Oxidation – lose electron Also called dehydrogenation 1. LEO says GER LEO = L ose E lectrons O xidation GER = G ain E lectrons R eduction 2. OIL RIG OIL = O xidation I s L osing RIG = R eduction I s G aining 2 R EDOX R EVIEW 1. Oxidation – lose electron (dehydrogenation ) 2. Reduction – gain electron (hydrogenation ) C O H R C OH H H R [Ox] [Ox] 1 Alcohol Aldehyde Carboxylic Acid C O OH R [Red] [Red] R EDOX R EVIEW 1. Oxidation – lose electron (dehydrogenation ) 2. Reduction – gain electron (hydrogenation ) C O R’ R C O H H R’ R [Ox] 2 Alcohol Ketone [Red] 3 R EDOX R EVIEW 1. Oxidation – lose electron (dehydrogenation ) 2. Reduction – gain electron (hydrogenation ) C OH R’’ R’ R 3 Alcohol No Reaction [Ox] R EDOX R EVIEW Oxidation reactions found in: Metabolism Formation of heart disease LDL oxidation Cancer Oxidation of DNA can initiate cancer Aging Oxidation can damage tissues & cause wrinkles 4 R EDOX R EVIEW COO- H C – O H CH 2 COO- COO- C = O CH 2 COO- Malate Oxaloacetate NAD + NAD H + H + Which reactant is oxidized? B IOLOGICAL I MPLICATIONS OF O XIDATION Beneficial Metabolism Cell signaling Kill bacteria Harmful Inactivate hormones Vitamin deficiencies Cell death Heart disease Cancer Alzheimer’s disease 5 Catalyzers of oxidation Enzymes (ex. lipoxygenase & myeloperoxidase ) Metals (ex. Fe, Cu, Co) UV light R EACTIVE S PECIES http://www.youtube.com/watch?v=T_Xo5AaTH8U 6 F REE R ADICAL C HEMISTRY Atom or molecule that has 1 or more unpaired electrons Denoted with • L • = lipid radical R • = non-lipid radical Oxygen (O) has 7 valence e- , 3 pairs & 1 unpaired - making it very reactive! O • • • • •• • F REE R ADICALS Can also be formed from: Metabolism Smoking UV light Drugs Pollutants Exercise Stress Alcohol Subluxation? 7 Reactive Species Reactive oxygen species (ROS) Radical (O•) Nonradical Reactive nitrogen species (RNS) Radical (N•) Nonradical • Superoxide (O 2 •- ) • Hydroxyl ( •OH) ROS Radicals • Singlet oxygen ( 1 O 2 ) • Hydrogen peroxide (H 2 O 2 ) ROS Nonradicals • Nitric oxide ( • NO) RNS Radical 8 S UPEROXIDE (O 2 •- ) Molecular oxygen ( 3 O 2 , triplet oxygen, ground state) 1s 2 2s 2 2p 4 Superoxide (O 2 •- ) 1s 2 2s 2 2p 5 O O • • • • • • • • • • • • O O • • • • • • •• • • • • • One unpaired e- Superoxide (O 2 •- ) During detoxification by cytochrome P 450 enzymes Molecular oxygen (O 2 ) steals e- from different compounds During normal metabolism in the electron transport chain Produced by respiratory burst in white blood cells Not able to diffuse through lipid bilayer (stuck in cell )....
View Full Document

This note was uploaded on 01/07/2012 for the course PHCH 51311 taught by Professor Nightingale during the Summer '11 term at Palmer Chiropractic.

Page1 / 31

Oxidation AOX 010510 2 slide - 1 O XIDATION & A...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online