Oxidation AOX 010510 wo pics

Oxidation AOX 010510 wo pics - REDOX REVIEW 1. Oxidation...

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1 O XIDATION NTIOXIDANT C HEMISTRY (P G . 417-425) Lia M. Nightingale, Ph.D. REDOX REVIEW 1. Oxidation lose electron Also called dehydrogenation 1. LEO says GER LEO = L ose E lectrons O xidation GER = G ain E lectrons R eduction 2. OIL RIG OIL = O xidation I s L osing RIG = R eduction I s G aining REDOX REVIEW 1. Oxidation lose electron (dehydrogenation ) 2. Reduction gain electron (hydrogenation ) C O H R C OH H H R [Ox] [Ox] 1 Alcohol Aldehyde Carboxylic Acid C O OH R [Red] [Red] REDOX REVIEW 1. Oxidation lose electron (dehydrogenation ) 2. Reduction gain electron (hydrogenation ) C O R’ R C O H H R’ R [Ox] 2 Alcohol Ketone [Red] REDOX REVIEW 1. Oxidation lose electron (dehydrogenation ) 2. Reduction gain electron (hydrogenation ) C OH R’’ R’ R 3 Alcohol No Reaction [Ox] REDOX REVIEW Oxidation reactions found in: Metabolism Formation of heart disease LDL oxidation Cancer Oxidation of DNA can initiate cancer Aging Oxidation can damage tissues & cause wrinkles
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2 REDOX REVIEW COO - H C – O H CH 2 COO - COO - C = O CH 2 COO - Malate Oxaloacetate NAD + NAD H + H + Which reactant is oxidized? REDOX REVIEW COO - HC H HC H COO - Succinate FAD FAD H 2 COO - HC HC COO - Fumarate Which reactant is oxidized? BIOLOGICAL IMPLICATIONS OFOXIDATION Beneficial Metabolism Cell signaling Kill bacteria Harmful Inactivate hormones Vitamin deficiencies Cell death Heart disease Cancer Alzheimer’s disease Catalyzers of oxidation Enzymes (ex. lipoxygenase & myeloperoxidase ) Metals (ex. Fe, Cu, Co) UV light REACTIVE SPECIES http://www.youtube.com/watch?v=T_Xo5AaTH8U FREE RADICAL CHEMISTRY Atom or molecule that has 1 or more unpaired electrons Denoted with L = lipid radical R = non-lipid radical Oxygen (O) has 7 valence e - , 3 pairs & 1 unpaired - making it very reactive! O ••
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3 FREE RADICALS Can also be formed from: Metabolism Smoking UV light Drugs Pollutants Exercise Stress Alcohol Subluxation? Reactive Species Reactive oxygen species (ROS) Radical (O•) Nonradical Reactive nitrogen species (RNS) Radical (N•) Nonradical Superoxide (O 2 - ) Hydroxyl ( •OH) ROS Radicals Singlet oxygen ( 1 O 2 ) Hydrogen peroxide (H 2 O 2 ) ROS Nonradicals Nitric oxide ( NO) RNS Radical SUPEROXIDE (O 2 - ) Molecular oxygen ( 3 O 2 , triplet oxygen, ground state) 1s 2 2s 2 2p 4 Superoxide (O 2 - ) 1s 2 2s 2 2p 5 O O •• O O •• One unpaired e- Superoxide (O 2 - ) During detoxification by cytochrome P 450 enzymes Molecular oxygen (O 2 ) steals e - from different compounds During normal metabolism in the electron transport chain Produced by respiratory burst in white blood cells Not able to diffuse through lipid bilayer (stuck in cell ). Is this a
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Oxidation AOX 010510 wo pics - REDOX REVIEW 1. Oxidation...

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