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bild lecture week 4.1

bild lecture week 4.1 - c.ii Gives energy because 3...

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Metabolism 1.) Metabolism: cell’s total chemical reactions. Energy/pathways dedicated to bond breaking/formation a. Catabolic: breakdown. b. Anabolic: builds up. Requires energy. 2.) Gibbs free energy: maximum energy in a system that is free to perform work. a. ΔG = change in free energy between reactants and products b. If ΔG<0, spontaneous reachtion, downhill, releases energy. Boulder rolling down hill c. Is ΔG>0, non spotaenous. Uphill, requires energy c.i. Exergonic reaction: energy released c.ii. Endergonic: requires energy c.ii.1. ΔG = ΔGf – Δgi 3.) Closed system G = o a. Cells = open system. Systems moving toward equilibrium can do work. 4.) Cellular work a. Mechanical work: movements, muscle contraction, b. Transport work: gradient, H+ proton pump c. Chemical work: biosynthesis, protein translation c.i. ATP = adenosine triphosphate. c.i.1. Triphosphate = 3x Pgroup c.i.2. Ribose + adenine+ triphosphate = ATP
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Unformatted text preview: c.ii. Gives energy because 3 phosphate group is unstable. By hydrolysis of one, the other are broken. = energy d. Endergonic reaction; ΔG is positive, reaction is not. d.i. ΔG=O = equilibrium d.ii. Judrplsus of eraction d.ii.1. Even though metabloic process is spontaneous, it usually must happen with a catalyst. 5.) Enzymes: Proteins that catalyze reactions to help them proceeed faster. 6.) Catalyse: speeds up reaction without insetl being consumedl 7.) Enzyme and substrate= ionic or h bond. 8.) If one time you are in surplus of a nutrient and the other day you’re not, you need to properly allocate energy inhibition of enzyme activity. 9.) Feedback inhibition: isoleucine synthesis: cascade of enzymes needed to make end product, isoleucine. Once it has enough, isoleucine can bind to one of the first intermediates and inhibit production. 10.)...
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