Kevin Notes Human Para..09.20

Kevin Notes Human Para..09.20 - Gi tract Fasciolopsis buski...

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Gi tract Fasciolopsis buski Metagonimus Yokogawa Heterophyes heterophyes Liver/Bile duct Fasciola hepatica Clonochis sinensis Lung Paragonius westermani Blood Schistosoma mansoni s. haematobium s. japonicum I. Fasciolopsis buski a. Intro i. ~10 mill cases ii. Asia + india iii. Very large adult 75mm x 20mm large intestinal fluke iv. Infects humans + pigs reservoir host (non-human animals that are DH serve as source of infection)
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b. Life cycle adult worm in SI eggs in feces miracidium penetrates snail sporocyst rediae 1 rediae 2 cercaria exit snail encyst on water vegetation metacercaria ingested by DH c. Pathalogy i. Light infection adult worms found in duodenum and jejunum of small intestine usually few symptoms of infection ii. Heavy infection worms throughout small intestine inflammation, ulceration, abscesses, abdominal pain malabsorption diarrhea bowel obstruction II. Metagonimus yokogawai (MY) / Heterophyes Heterophyes (HH) a. Life cycle 1 st IH =Snail sporocyst 2 generations of rediae cercariae infect 2 nd IH = fish metacercariae ingested by DH = human or other mammals b. Morphology - very small 1.4mm x 0.5 mm both species have ventral suckers which are muscular attachment organs gonatyl, sucker that surrounds genital pore (opening of repro. Ducts) HH : VS+ gonatyl along midline MY : Vs & gonatyl fused and off center = genital acetabulum c. Pathology i. Adults in SI generally no symptoms large # leads to inflammation and ulceration ii. Eggs adults are so small that they burrow into intestinal musosa, erode kusha eggs can get into blood eggs carried to ectopic sites, like heart leading to failure, CNS can lead to neurological disorders
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III. Fasciola hepatica a. Intro i. 30mm x 13mm ii. Sheep liver fluke parasite of cattle and sheep reservoir hosts causes liver rot trematodes leads to losses in animal prod iii. Human infection 2-17 million cases worldwide b. Life cycle IH =Snail sporocyst generation
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Kevin Notes Human Para..09.20 - Gi tract Fasciolopsis buski...

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