{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Chapter 16 - Chapter 16 The Molecular Basis of Inheritance...

Info icon This preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 16: The Molecular Basis of Inheritance 16.1: DNA and Genetic Material - Evidence that DNA can transform bacteria o Griffith mixed two strands of Heated pathogenic (harmful) and one non pathogenic (harmless) The heated pathogenic= dead Result: some of the non pathogenic living cells became pathogenic Conclusion: some chemical component of the dead pathogenic cells caused this heritable change Griffith called this “transformation” - Evidence that viral DNA can program cells o Phages- viruses that eat bacteria o Hershey and Chase’s experiment Result: radioactive phage DNA in pellet and radioactive phage proteins in liquid Conclusion: DNA functions as the genetic material of phage T2. - Evidence that DNA is genetic material o Chargaff noticed that base composition of DNA varies from one species to another>>molecular diversity o He also noticed the ratio of nucleotide bases o Chargaff’s rule= A-T and G-C o 5 end at phosphate and 3 end at the OH - Building a Structural Model of DNA: Scientific inquiry o Rosalind Franklin-photograph of DNA o Watson and Crick studied the photos and discovered that… DNA= helical shape Certain width b/w helix and nitrogenous base All together= double helix!! o Built double helix DNA Bases= hydrophobic and held by hydrogen bonds ( that’s why they are faced inward) Sugar phosphate backbone Anti-parallel Van der waals= holding molecules together 16.2: Many proteins work together in DNA replication and repair - DNA replication: Closter look o Semi-conservative model: two strands of parental molecule separate and each function as a template for synthesis of a new complementary strand. o Origin of replication- where DNA replication starts o Prokaryotes Circular and has a single origin Forms a bubble so that DNA goes both directions until the entire molecule is copied o Eukaryotes Have hundreds of origins Multiple bubbles in both directions Thus, speeds up replication o At each end of origin= replication fork Where parental DNA is being unwound
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Helicase= enzyme that untwists DNA to separate the parental cells making them available as template strands Single strand binding protein- bind to unpaired DNA strands to stabilize them Untwisting of double helix causes tighter twisting and strain ahead of the replication fork
Image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern