3122012WtrOutlineChapter1PP

3122012WtrOutlineChapter1PP - Cancer 1 Cancer statistics...

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Cancer 1
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Cancer affects one in three people; estimated  569,490 Americans would die of cancer in 2010 Worldwide incidence of cancer is about 10 million  cases/year Cancer statistics 2
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Cancer is a group of diseases characterized by  unregulated cell growth  Invasion of adjacent tissues Spread of cells from the site of origin (primary site)  to other sites in the body (metastases What is cancer? 3
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Carcinogenesis Process of inducing cancer Cancer is essentially a  disease at the level of  DNA, i.e., the  molecular biology of cancer What is cancer? 4
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Carcinomas: epithelia [80% of cancers] Squamous cell carcinomas [protective cell layers such  as skin, lung, esophagus, cervix, etc.  Think what these cells are exposed to in the colon, bile  duct, lungs and skin] Adenocarcinomas [secretory epithelia such as  lung, colon, breast, pancreas, stomach,  esophagus, prostate, endometrium, ovary, etc.] Cancer is a group of diseases 5
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Sarcomas: connective [mesenchymal] tissue [1%  of cancers] Osteosarcomas, fibrosarcomas, chondrosarcomas, etc. Hematopoietic tumors: the blood-forming tissues  and immune tissues Leukemias and lymphomas, etc. Neuroectodermal tumors: nervous tissue Gliomas, etc Cancer is a group of diseases 6
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Cell division is usually a closely regulated  in cancer Unregulated cell growth 7
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Cancer is a disease of multicellularity [Aggregate  number of cells formed during an average human  lifetime: 1016].  Each time a cell divides there are many things that can  go wrong. ..more about the regulation of cell division later  on. .. Cell division is a normal biological process  [growth, development, repair] but one that creates  a risk of cancer] Unregulated cell growth 8
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220 cells are almost undetectable 230 cells is a small lump (about a 1 cm mass) More than 1 billion cell clumped together 240 cells is a large tumor A dime is 1.5 cm Uncontrolled Cellular Growth 9
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Malignant tumors: do spread or metastasize oxygen Invasion and spread of cells 10
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Cancer cells vs. normal cells Normal Cells In cell culture  conditions: cell contact  inhibition:  Cell surface receptors  recognize contact with  other cells with contact  triggering the internal  pathways that inhibit  division by arresting the  cell cycle, usually in the  G1phase 11
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Cancer cells vs. normal cells
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This note was uploaded on 01/09/2012 for the course BIO 242 taught by Professor Jimellinger during the Spring '12 term at Bellevue College.

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3122012WtrOutlineChapter1PP - Cancer 1 Cancer statistics...

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