Exam 4 - Exam 4. introduction to Microbiology MICR 2123...

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Unformatted text preview: Exam 4. introduction to Microbiology MICR 2123 November 30, 2011 Part I. Multiple Choice. Circle the letter of the one most correct answer for each. Worth 2.5 points each. as}; 1) Which of the following environments would normall be free of microbes in a healthy individual? a) intestinal tract b) Mouth b) Skin @Lung d) Genitourinary tract 2) These are phagogtic cells that normally engulf and destroy bacteria found in your blood or tissues. They are important in antigen presentation for a humoral immune response. a) B cells b) Tc cells c) Plasma cells @Macrophages 3) 95;) is the: 3) Dose of organisms that will cause an infection in 50% of a test population b) Dose of microorganisms toxin that will kill all of a test population c) Dose of organisms that will cause an infection in all of a test population ‘16)} I ose of microorganisms that will kill 50% of a test population 4) Which of the following cell types recognize antigens displayed on an antigen presenting cell (APC) if the, APC also hasflMHC class II on its surface? cells b).‘TH2 cells c) B cells m/Plasma cells fifhllacrophages 5) Of the following bacterial pathogens, the one that is the typical cause of an epidemic life threatening watery diarrhea caused by an exotoxin that elevates cyclic AMP levels in intestinqlflcells is: a) Shigella dysenteriae MfiHelicobacter pylori c) Rotavirus @Wibrio cholerae 6) Neisseria meningitidis and Streptococcus pneumoniae possess which are probably their most im ortant virulence factors? a) Pili b) Endotoxins d) Exotoxins 7) Complement proteins are able to kill bacteria by: a) Neutralizing adhesins @Forming a membrane attack complex (MAC) c) inhibiting protein synthesis d) Attracting antibodies to the bacterial surface 8) The most common cause of watery travelers’ diarrhea is which of the following? a) Shigella dysenteriae b) Enterotoxigenic E. coli c) Rotavirus @ Vibrio cholerae 9 I reign molecule that specifically induces an immune response is referred to by the general term: _ Antigen b) Antibody c) lmmunoglobulin 5;;d):lmmunogen 10) Which of the following antibody types is the most abundant type found in mucosal secretions such as live and tears? 8A b) leE c) IgM d) lgG 11. The exotoxin made by Clostria'ium botulinumeads to: a) Hemolyitic uremic syndrome Flaccid paralysis c) Spastic paralysis 7-; Sterility Part ll. Fill in the blank. Complete the following lists or fill in the blank sentences with the most correct answer. Points are indicated for each and partial credit is possible. 21. Give four different properties that are specific to endotoxins in the left column and four : CONTRA§1IN§ properties that are specific to exotoxins in the right column (16 points total) 92m Win No Army?) 5‘ g ' (.49.; fat ‘Lri‘ei. x l .« “T 3&5 22. ' A E C. cells (specific cell or class of cells) possess major histo- compatability (MHC) class II (MHC—ll) on their surface while A'} S g Q XK§ possess MHC-l on their surfaces. (4 points) 23. inflammation is a nonspecific reaction that is an important nonspecific first line of protection against infection. Two of the four hallmarks (signs) of inflammation are: 7 (4 points total) E Qci smfiég we; i 25.3% 24. What are the two most important properties of the adaptive immune response: (4 points) b) I ELQfiE'fif‘g it a) .5 26. » . is a general term that describes the severity of a disease caused by a pathogenic microorganism.‘ (2 points) (MW 28. In Rheumatic fever and Rheumatic heart disease, cross reactive antibodies are formed (leading to autoimmunity) due to an infection caused by the pathogen response against the pathogen’s afimbrial adhesins which are called called M "V \f . ' :3, WC" This happens long after the occurrence of the original soft tissue infection caused byF this organism. This . iii/Vt?“ \Q A? original soft tissue infection is typically called - ' . (6 points) 29. An insect involved in the transmission of disease would be referred to as a Vfl g it); j ,4} (2 points) 30. For the important pathogen E. coli 0157:H7, the O serotype designation refers to the makeup of its while the H serotype designation refers to the antigenic nature of its . (6 points) éycafius oducedibyy It $§al pathogens are most often important for . . » . nt-ofilfié‘pa ogen to a host animal’s cells or tissues ‘/ Ikb) Nonspecific attachment of a pathogen to an inert surface @Wreventing phagocytosis ‘6) Promoting invasion of a host cell 13. Bacteria such as Shigella dysenteriae or Salmonella typhimurium use their to promote invasion of intestinal host cells. f. Pili (Fimbriae) . Type lll secretion systems ——————._____.__________ b) Capsules d) Exotoxins 14. An important nosocomial pathogenrthat is responsible for a number of soft tissue diseases and which is often highly antibiotic resistant is: a) Streptococcus pyogenes @Stophylococcus oureus estis d)~$tfepteeoecaspnewnoniae‘ 15. Which of the following pathogens is responsible for a type of sexually transmitted disease (STD) that is often asymptomatic which allows it to cause potentially severe long term effects? Chlamydia trachomatis bHreponemapal/idum w.rurmpathoge'nicff‘coli d)«Rotavirus 16. Toxic shock syndrome is caused by Staphylococcus aureus due to release of an exotoxin that is classified as a a) Membrane disrupting toxin c) Protease Supera ntigen ‘9 Protein synthesis inhibiting toxin 17. For which of the following is there already a rotective toxoid vaccine? “El .u. I "I .lim i \clRetavirus )Smallpox 18. An important pathogen that infects approximately one third of the world’s human population and is responsible for a chronic disease that results in more than two million deaths per year is: a) Yersinia pestis 2, » Mycobacterium tuberculosis c) Staphylococcus aureus d) Streptococcus pneumoniae 19. Which of the following toxins would be most likely to cause direct damage to the membranes of cells flinyour body? 4 /@fipid A a )g‘u—toxin W 20. Which of the following uses afimbrial adhesins for attachment to ciliated cells in the res irato tract to cause whooping cough? Bordetella pertussis c) Streptococcus pneumoniae b) Tetanus toxin c) Cholera toxin b) Mycobacterium tuberculosis d) Vibrio cholerae ...
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This note was uploaded on 01/10/2012 for the course MICR 2123 taught by Professor Hathorn during the Fall '08 term at Oklahoma State.

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Exam 4 - Exam 4. introduction to Microbiology MICR 2123...

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