SepsisBriefOverview

SepsisBriefOverview - Sepsis Overview December 5, 2006...

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Sepsis Overview December 5, 2006
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Sepsis Continuum of clinical pathophysiology and severity Process rather than an event Mild dysfunction to frank organ failure Changes in the function of every organ system mediated by the host immune system.
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Sepsis Systemic Inflammatory Response Syndrome-ACCP/SCCM Consensus Temperature >38°C or <36° Heart rate >90 bpm Respiratory Rate>20 or PaCO 2 <32mmHg WBC>12,000/μl or <4,000/μl
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Sepsis Sepsis: 2 or more- Tachycardia >90bpm Rectal temp>38°C or <36°C Tachypnea(>20bpm) With 1 or more Alteration in mental status Hypoxemia (PaO 2 <72mmHG at FiO 2 0.21) Elevated plasma lactate Oligouria
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Sepsis Severe Sepsis Tachycardia >90bpm Rectal temp>38°C or <36°C Tachypnea(>20bpm) or PaCO 2 <32mmHg Hypotension despite fluid resuscitation Presence of perfusion abnormalities: lactic acidosis, oligouria, alteration in mental status
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Sepsis Mediators of Sepsis Lipospolysaccharide (gram-negative bacteria) Lipoteichoic acid (gram-positive bacteria Peptidoglycan Cytokines IL-1 – mediates systemic effects of infection IL-6 – effects liver function TNF-α- potentiates the activation of neutrophils and macrophages IL-8 – regulates neutrophil function, mediates lung injury in sepsis
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Sepsis Mediators of Sepsis Complement Nitric Oxide Lipid Mediators: Chemotaxis, Cell activation, Vascular Permeability Phospholipase A2 PAF Eicosanoids
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Sepsis Mediators of Sepsis Adhesion Molecules Selectins Leukocyte Antigens
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Sepsis
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This note was uploaded on 01/12/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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SepsisBriefOverview - Sepsis Overview December 5, 2006...

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