EVOLUTION/LECTURE1file:///C|/Wilma's%20stuff%20NEW/WSFTP/newbio/syllabus/Sp%2012/Evolution_Ortega/chapter1AIDS_SPR.html[12/7/2011 9:27:41 AM]Evolution(PCB 4674).Chapter 1. A case for evolutionary thinking:Understanding HIVMain topics of lecture:I.- General background:1.- HIV and evolutionary studies: Understanding adaptation anddiversity2.- The natural history and geography of the HIV epidemic3.- What is HIV?4.- How does HIV cause AIDS?II.- AIDS and evolutionary biology:5.- Searching for a drug capable of combating AIDS. The case of AZT6.- Why is HIV fatal?7.- Why are some people resistant to infection by HIV?8.- Could a vaccine provide protection from diverse strains of HIV?9.- What, if anything, does evolutionary biology have to say about waysto stem the AIDS epidemic?I.- General background:1.- HIV and evolutionary studies: Understanding adaptation anddiversity1.1.- Evolution is one of the most relevant scientific fields for the everyday life of all of us.The Human Immunodeficiency Virus(HIV) provides an excellent example of why it isimportant to understand evolution and its consequences. The HIV is a pathogen that causes theAcquired Immune Deficiency Syndrome(AIDS).1.2.- HIV is a compelling case study because it raises issues that are almost certain to influencethe professional and personal lives of all of us. AIDS already qualifies as one of the mostdevastating epidemics EVER EXPERIENCEDby our species.1.3.- Four of the major questions on AIDS demonstrate the value of evolutionary studies for allof us. These four questions are:- Why have promising AIDS treatments, like the drug azidothymidine(AZT), provenineffective in the long run?
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