MattsPresentation1(2)

MattsPresentation1(2) - Introduction Into Cubic Phase...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Introduction Into Cubic Phase Lipids Matt Chandler
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Polymorphism In general, it describes multiple possible states for a single property. Also known as mesomorphism. Ex. Carbon can exist as diamond or graphite.
Background image of page 2
Polymorphism in Lipids The ability of a given mixture of lipids to form crystallographically diverse structures. A - lamellar liquid crystal phase, L α . B - inverted hexagonal phase, H II. C - hexagonal phase, H I.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Why Study Lipid Polymorphs? They exhibit the broadest range of polymorphic structures of any known class of molecules. By studying the structural polymorphism observed with isolated lipids, we can gain an understanding of the forces that are locked up in biomembranes and that affect the organization and function of proteins.
Background image of page 4
Terminology Non-Bilayer Phase - nonlamellar phase, or liquid crystalline phases that are not L α phases. Inverted or Water-In-Oil Phase - refers to one in which the lipid/water interface has the same sign curvature as an H II phase, i.e. a net concave curvature when viewed from the water domain. Liquid-Crystalline - refers to phases that are intermediate to the rigorously crystalline solids and true isotopic liquids, including systems that do not have long flexible chains.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Lipid Phases We try to understand the physical basis of lipid phases, because an understanding of this basis gives insight into the forces at play in lipid bilayers. A polar biomembranes lipid interaction with water allows for a variety of structures, or polymorphs, not normally found in cells. These include, lipid bilayers, as well as tubes, rods (hexagonal phases), and three dimensional assemblies, aka cubic phase lipids.
Background image of page 6
Lamellar Crystalline Phase, L α Bilayer (cylindrical). Composed of lipid
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 01/12/2012 for the course BBA 2005 taught by Professor Staff during the Fall '11 term at University of Florida.

Page1 / 22

MattsPresentation1(2) - Introduction Into Cubic Phase...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online