MattsPresentation1(2) - Introduction Into Cubic Phase...

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Introduction Into Cubic Phase Lipids Matt Chandler
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Polymorphism In general, it describes multiple possible states for a single property. Also known as mesomorphism. Ex. Carbon can exist as diamond or graphite.
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Polymorphism in Lipids The ability of a given mixture of lipids to form crystallographically diverse structures. A - lamellar liquid crystal phase, L α . B - inverted hexagonal phase, H II. C - hexagonal phase, H I.
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Why Study Lipid Polymorphs? They exhibit the broadest range of polymorphic structures of any known class of molecules. By studying the structural polymorphism observed with isolated lipids, we can gain an understanding of the forces that are locked up in biomembranes and that affect the organization and function of proteins.
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Terminology Non-Bilayer Phase - nonlamellar phase, or liquid crystalline phases that are not L α phases. Inverted or Water-In-Oil Phase - refers to one in which the lipid/water interface has the same sign curvature as an H II phase, i.e. a net concave curvature when viewed from the water domain. Liquid-Crystalline - refers to phases that are intermediate to the rigorously crystalline solids and true isotopic liquids, including systems that do not have long flexible chains.
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Lipid Phases We try to understand the physical basis of lipid phases, because an understanding of this basis gives insight into the forces at play in lipid bilayers. A polar biomembranes lipid interaction with water allows for a variety of structures, or polymorphs, not normally found in cells. These include, lipid bilayers, as well as tubes, rods (hexagonal phases), and three dimensional assemblies, aka cubic phase lipids.
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Lamellar Crystalline Phase, L α Bilayer (cylindrical).
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