Bio1_17_DNA1 - 1 2 1 2 3 4 1 2 5 6 7 8 9 10 1 11 Overview...

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1 Overview: DNA • Ch. 12: Molecular Biology of the Gene – The genetic material – Replication of DNA – The genetic code of life The Genetic Material • Must be able to: – Store information – Be replicated – Undergo rare changes (mutations) • Candidates: – Proteins with 20 different amino acids – DNA with 4 different nucleotides The Genetic Material: DNA • 1868: DNA discovered (Miescher) • 1931: Transformation discovered (Griffith) • 1944: DNA transforms bacteria (Avery, et al.) • 1950s: DNA shown to be hereditary material – DNA is helical (Franklin) Transformation of Bacteria • Frederick Griffith – Something passed from dead S to live R •Transforming principle • Oswald Avery – DNA from S strain transforms R strain – DNase prevents transformation – Protease had no effect Assignment 1 • Think, Pair, Share • Topic: Why did an injection of both living IIR cells and dead IIIS cells kill the mice when each of those cells individually did nothing? Assignment 2 • Think, Pair, Share – Topic: Predict what results would be expected if DNA is the hereditary material in Avery’s experiment. Which treatments will develop live S cells? Which will not? Avery’s Experiments Assignment 3 • Think, Pair, Share • Topic: Why were no IIIS cells found in the mixture containing deoxyribonuclease, but they were found in the mixtures containing ribonuclease or protease? Transformation of Organisms
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Bio1_17_DNA1 - 1 2 1 2 3 4 1 2 5 6 7 8 9 10 1 11 Overview...

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