LecturesPart21

LecturesPart21 - Computational Biology Part 21 Cell Cycle...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Computational Biology, Part 21 Cell Cycle Modeling Robert F. Murphy Copyright 2005-2006. All rights reserved. Assigned Reading s Computational Cell Biology by Fall et al, Chapter 10 through section 10.5 (handed out in class) Cell Cycle model s Rise in cyclin/Cdk triggers transition to S phase s Also causes inhibition of active APC s Active APC degrades cyclin Cell Cycle model dX = k1 - ( k 2 + k2Y )X dt dY ( k 3 + k 3 A)(1- Y ) k 4 mXY = dt J 3 + 1- Y J4 + Y X=cyclin/CDK dimer Y=active Cdh1/APC complex m=cell mass A=Cdh1 activator Cyclin/Cdk vs. APC phase plane s (Maple worksheet CompCellBiolFigure103.mw) Bifurcation of cyclin/Cdk vs. "p" phase plane s (Maple worksheet CompCellBiolFigure104.mw) Cell Cycle model dX = k1 - ( k 2 + k2Y )X dt dY ( k 3 + k 3 A)(1- Y ) k 4 mXY = dt J 3 + 1- Y J4 + Y dA k5 (mX) n = k5 + n - k6 A n dt J 5 + (mX ) dm m = mm(1) dt m* X=cyclin/CDK dimer Y=active Cdh1/APC complex m=cell mass A=Cdh1 activator Kinetics of cell cycle changes in cyclin and APC s (Maple worksheet CompCellBiolFigure106.mw) ...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern