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Cell Signalling - Chapter 5 Control of Cells by Chemical...

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The chemical properties of a ligand predict its binding site: Hydrophobic/lipid-soluble: cytosolic or nuclear receptors examples: steroid hormones, thyroid hormones… Hydrophilic/lipid-insoluble: membrane-spanning receptors examples: epinephrine, insulin… Chapter 5 Control of Cells by Chemical Messengers = How hormones and other signals work Communication requires: signals (ligands) and receptors (binding proteins).
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Receptors are proteins that can bind only specific ligands and they are linked to response systems. Hydrophobic signals typically change gene expression, leading to slow but sustained responses. Hydrophilic signals typically activate rapid, short-lived responses that can be of drastic impact. Chapter 5 Control of Cells by Chemical Messengers = How hormones and other signals work (cont.)
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Figure 5-1 Receptors on the surface of a cell are typically proteins that span the membrane.
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