Endocrine System

Endocrine System - Endocrine Physiology Learning...

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BMED 3161 Endocrine Physiology Learning Objectives: Describe general principles of endocrinology Be able to define and classify hormones Describe hormone release mechanisms and control pathways
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BMED 3161 Neuroendocrine Pathways
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BMED 3161 Neuroendocrine Pathways
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BMED 3161 Interactions between the nervous and endocrine systems emphasize their coordinated communications function. Figure 11-11
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BMED 3161 Classic All All are separate glands that could be easily identified and removed. Hormones can come from other sources, as well. Endocrine Glands
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BMED 3161 The first recorded endocrine experiment involved the castration of roosters. They lost sex drive and had reduced comb size. Reattachment of the testes resulted in return of these male traits. Since no nerves were reattached, it was concluded that something was be secreted from the glands. – 1849 (Berthold)
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BMED 3161 Classic Steps for Identifying Endocrine Glands 1. Induce state of hormone deficiency 2. Replacement therapy should eliminate symptoms of hormone deficiency 3. Implant gland or extract from gland into a normal animal symptoms of hormone excess 4. Purify extracts, separate active substance; design biological assay, inject animal with purified extract and monitor for response
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BMED 3161 Hormones (termed in 1905, from Greek “to excite or arouse”) • Chemical messengers secreted into the blood by endocrine cells or specialized neurons that elicit a biochemical response at a distant target. • Exerts effect at conc. (10 -9 -10 -12 M) • Half-life = amount of time required to reduce a hormone concentration by half 1. Indicates rate of hormone breakdown 2. Indicates how long a hormone remains in the body
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Types of Hormones (See Table 11-1) 1. Peptide hormones 2. Steroid hormones 3. Amine hormones Differ on basis of: – synthesis – storage –r e l e a s e – transport – cellular mechanism of action Neurosecretory hormones are either peptide or amine. Exclusion rule: If a hormone isn’t
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Endocrine System - Endocrine Physiology Learning...

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