Exercise Physiology Exercise is a disruption in homeostasis Feed forward responses: ↑HR, ↑ventilation rate 1. Metabolism and exercise Exercise demands a steady supply of ATP, which requires oxygen and other fuels ATP: Small amount from sarcoplasm Prosphocreatine breakdown donates P to ADP These only produce enough energy for ~10-15 sec of contraction Carbohydrates and fats are primary substrates Aerobic pathways are most efficient for ATP production Uses free fatty acids and glucose Anaerobic – when O2 requirements > O2 supply Pyruvate →lactic acid ATP production 2.5X faster than aerobic, but only produces1ATP/glucose Glucose: Plasma glucose pool Intracellular stores of glycogen Glucose production from nonglucose precursors Hormones that affect glucose, fat metabolism are secreted during exercise Glucagon, catecholamines, cortisol Insulin secretion decreases despite increasing plasma glucose levels Sympathetic suppression of insulin secretion Reduces glucose uptake by non-muscle cells
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Adenosine triphosphate, Water intoxication