Immune-Inflammatory - Defense Mechanisms: Immune System...

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BMED 3100 Defense Mechanisms: Immune System • Cells mediating immune defenses • Nonspecific defense – Inflammation – Example: biomaterials • Specific defense – B and T cells – Antibodies – Examples: infectious diseases, stress, autoimmune diseases, hypersensitivity • Vander, Ch. 18
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BMED 3100
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BMED 3100
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BMED 3100 Macrophage activity not only kills the invading microbes, but also 1) results in the secretion of chemical signals which recruit wider participation in the non-specific response to the invasion, and 2) activates complement proteins, which increase local blood supply and further enhance phagocyte function. Macrophages
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BMED 3100 Inflammatory Responses to Biomaterials protein adsorption/coagulation protein adsorption/coagulation Inflammation limits Inflammation limits in vivo in vivo biological performance biological performance Strategies to modulate inflammation Strategies to modulate inflammation protein adsorption protein adsorption -resistant coatings (e.g., PEG) resistant coatings (e.g., PEG) release of anti release of anti
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This note was uploaded on 01/12/2012 for the course BMED 3110 taught by Professor Staff during the Spring '08 term at Georgia Institute of Technology.

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Immune-Inflammatory - Defense Mechanisms: Immune System...

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