Movement and Parkinson_s - Parkinson's Disease (PD) (see...

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1 Parkinson's Disease (PD) (see also slides) Epidemiology: usually middle-aged to elderly-peak age of onset between 58-62 years. (although 5-10% present before age 40) More common in males 130-150 per 100,000 person; 40,000 new cases/year - US Etiology: unknown, but evidence points to a combination of accelerated aging, genetic predisposition, exposure to toxins, viral agents, and an abnormality in oxidative mechanisms Symptoms/Diagnosis: rigidity/akinesia, bradykinesis, tremors, and impaired postural reflexes; Patients usually present with movement problems such as a festinating gait, cogwheel rigidity of the limbs, poverty of voluntary movement, and a pill rolling type of tremor at rest. Dysaththria, dysphagia; no paralysis; symptoms are bilateral. In time the patient's facies will become mask-like. Usually mental deterioration does not occur but some patients may show some sign of dementia (up to 40%) as the disease progresses; depression.
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This note was uploaded on 01/12/2012 for the course BMED 3110 taught by Professor Staff during the Spring '08 term at Georgia Institute of Technology.

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Movement and Parkinson_s - Parkinson's Disease (PD) (see...

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