9 - Cytoskeleton II Actin

9 - Cytoskeleton II Actin - Lecture 9: Intermediate...

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Lecture 9: Intermediate Filaments and Actin
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Intermediate Filaments One intermediate filament found in nucleus of most eukaryotic cells: lamin (A, B, C flavors) Duplications of lamin gene led to existing family of intermediate filament proteins
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Table 16-1 Molecular Biology of the Cell (© Garland Science 2008) Types of Intermediate Filament Proteins
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Compare/Contrast IFs with MTs and actin Similarities: All are polymers All can show a range of dynamic behaviors Differences: IFs do not bind or hydrolyze nucleotides IFs are not polar IFs do not have a dedicated motor
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Figure 16-19 Molecular Biology of the Cell (© Garland Science 2008) The pathway of Intermediate Filament Assembly
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Intermediate Filaments can be bundled together into filament arrays neurofilaments in axons filaggrin-mediated bundling of keratin in skin
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Figure 16-9 Molecular Biology of the Cell (© Garland Science 2008) Intermediate Filaments are strong and flexible
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Figure 16-20 Molecular Biology of the Cell (© Garland Science 2008) The organization of keratins in ephithelial cells Note regions of cell-cell contact
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Figure 16-21c Molecular Biology of the Cell (© Garland Science 2008) Mutant keratins cause a variety of diseases that afflict epidermal cells human genome encodes up to 50 different keratins
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Actin
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Actin shares some characteristics with tubulin Actin, like tubulin, forms a repeating
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9 - Cytoskeleton II Actin - Lecture 9: Intermediate...

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