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Unformatted text preview: impact, you have to obtain less than 5% of the undesired diasteroisomer (which you know will be separated during recrystallization). Please indicate the preference, in kcal/mol, that you have to achieve and specify how (i.e. with which equations) you can obtain this value. (2 points) O H H 2 e) Carbamates, such as the BOC ( t-b utyl o xy c arbonyl) group, are priviledged protecting groups for nitrogen atoms. The popularity of the BOC group is linked to: 1) its electron withdrawing nature, which attenuates the nucleophilicity of the nitrogen; 2) the fact that it can be removed cleanly under acidic conditions; AND 3) the fact that the carbonyl is inert in the presence of various nucleophiles. Using stereoelectronic arguments, please account for this attenuated electrophilicity. (2 points) R N R' O O Me Me Me R NBoc R'...
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