423f11-protfold

423f11-protfold - Protein Folding CMSC 423 Proteins mRNA =...

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Protein Folding CMSC 423
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Proteins V C R R residue AGG GUC UGU CGA R V C R mRNA = {A,C,G,U} protein | | = 20 amino acids Amino acids with fexible side chains strung together on a backbone Function depends on 3D shape
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Examples of Proteins Alcohol dehydrogenase Trypsin: breaks down other proteins Antibodies Collagen: forms tendons, bones, etc. Examples of “Molecules of the Month” from the Protein Data Bank http://www.rcsb.org/pdb/ TATA DNA binding protein
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Backbone Protein Structure
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Backbone Protein Structure Side-chains
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http://www.jalview.org/help/html/misc/properties.gif
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1tim Alpha helix Beta sheet
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Alpha Helix Suggested from theoretical consideration by Linus Pauling in 1951. C’=O of residue n bonds to NH of residue n + 4
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antiparallel parallel Beta Sheets
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Structure Prediction Given: KETAAAKFERQHMDSSTSAASSSN… Determine:
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http://boinc.bakerlab.org/rah_about.php Folding Ubiquitin with [email protected]
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CASP8 Ben-David et al, 2009 Critical Assessment of protein Structure Prediction Target Best Prediction
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Structural Genomics Space of all protein structures Determined structure
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This note was uploaded on 01/13/2012 for the course CMSC 423 taught by Professor Staff during the Fall '07 term at Maryland.

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423f11-protfold - Protein Folding CMSC 423 Proteins mRNA =...

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