Biophysical Chemistry I, Fall 2010Homework Assignment #4, due Oct. 211. Go tohttp://w3dna.rutgers.edu. Ask to analyze PDB code 1BNA, whichis the crystal structure of the “Drew-Dickerson dodecamer”, whichwas the first atomic level resolution crystal structure of DNA to be re-ported. What is the nucleic acid sequence of this short piece of DNA?Compare the sequences of the two strands; why do think this relationwas important? (Save the files here, or bookmark this page, since youwill need to return to it below.)2. At the same web site, go back to the home page and click on “re-construction”. This provides a facility to build a structure (given itssequence) from a fiber-diffraction model. (X-ray analysis of fibers ofDNA was the principal method used from the 1950’s to the 1970’s toexplore the structure of DNA; it is an averaged process, which doesnot provide structures that are sequence-specific.) Choose a “B-DNAgeneric” fiber model and reconstruct the model using the sequencefrom part 1 above. Download the resulting PDB file, go back to the
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