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Biol 112 - Sept. 28 (C)

Biol 112 - Sept. 28 (C) - #$!$ Diseases and protein...

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!"#$%#!$&& & Diseases and protein structure: Three cases. Case 1. '()*+, ),++ ./,0(. 12 34(+5 678,9 : 0;+,)<+,= ;> 6?, [email protected];6,(/ ?,0;A+;2(/ =6()* 6;A,6?,@ 6; 0.*, . B6,[email protected],@CD E4; 4.7= 6; =?;4 6?, [email protected]<)6<@,D '()*+, ),++ ./,0(. F/ 0;=6 );00;/ >;@0 ;> 6?, ?<0./ 5(=,.=, sickle cell anemia, 6?, .0(/; .)(5 A+<6.0() .)(5 (= @,8+.),5 4(6? 6?, .0(/; .)(5 G.+(/, .6 8;=(6(;/ H 3I+<HJ.+9 (/ 6?, 2+;;5 [email protected];6,(/ ?,0;A+;2(/D F/ 0./7 @,A(;/= ;> K>@().L 6?, [email protected],G.+,/), ;> 6?, 12 ' 0<6.6(;/ 3I+<HJ.+9 (= .= ?(A? .= !MNOPMNL 4(6? ./ ,=6(0.6,5 &M 0(++(;/ K>@()./= .>>,)6,5 27 =()*+, ),++ 5(=,.=, E?, 0<6./6 ?,0;A+;2(/L 312 '9L >;@0= )?.(/= ;> 6,[email protected],@= E?,=, )?.(/= 5(=6;@6 6?, @,5 2+;;5 ),++=D E?, =()*+, ),++= 2+;)* [email protected],@(,=
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!"#$%#!$&& ! E?, >;@0.6(;/ ;> 6?, )?.(/= ;> 6,[email protected],@= (= . )?./A, (/ 4?()? +,G,+ ;> 1,0;A+;2(/ [email protected]<)6<@,Q KD [email protected]([email protected] SD ',);/[email protected] TD E,@6([email protected] UD V<.6,@/[email protected] WD K++ ;> 6?, .2;G, E?, )?./A, ;> A+<6.0() .)(5 .6 8;=(6(;/ H 6; G.+(/, (/ =()*+, ),++ 1,0;A+;2(/ (= . )?./A, (/ 4?()? +,G,+ ;> 1,0;A+;2(/ [email protected]<)6<@,Q K [email protected]([email protected] KD SD ',);/[email protected] TD E,@6([email protected] UD V<.6,@/[email protected] WD K++ ;> 6?, .2;G, X?()? ;> 6?, +,G,+= ;> ?.,0;A+;2(/ [email protected]<)6<@, (= 0;=6 +(*,+7 6; 2, unaffected 27 6?, )?./A, ;> A+<6.0() .6 8;=(6(;/ H 6; G.+(/,Q KD [email protected]([email protected] S ',);/[email protected] SD TD E,@6([email protected] UD V<.6,@/[email protected]
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!"#$%#!$&& P Case 2. Mad Cows and misfolding. E?, [email protected] [email protected];6,(/ (= . [email protected];6,(/ /;@0.++7 >;</5 ;/ 6?, =<@>.), ;> /,@G, ),++=D F6Y= ></)6(;/ (=/Y6 @,.++7 )+,[email protected] F6 )./ .5;86 . 5(>>,@,/6 =?.8, >@;0 6?, /;@0.+ ;/, =?;4/D F> 6?(= 0(=>;+5,5 [email protected] A,6= (/6; 6?, 2+;;5L (6 4(++ (/6,@.)6 4(6? 6?, /;@0.+ [email protected] ./5 (/5<), 6?,0 6; )?./A, =?.8,D R()6<@, ;> 0(==>;+5,5 [email protected] 6?, ,+,)[email protected];/() =;<@), (=/Y6 .G.(+.2+, .6 6?, 0;0,/6D [email protected];8;=,5 /;@0.+ [email protected];8;=,5 0(=>;+5,5 E?, [email protected]= =6()* 6;A,6?,@ 6; >;@0 )+<=6,@= ;@ >([email protected],=D E?,=, >([email protected],= 5,[email protected];7 /,@G, ></)6(;/ [email protected]()<[email protected]+7 (/ 6?, [email protected](/D '; (/A,=6(/A 6?, 0(=>;+5,5 [email protected];6,(/ )./ [email protected],.5 0(=>;+5(/AD E?, 0(=>;+5(/A );/6(/<,= 6; [email protected],.5 .)6= +(*, ./ B(/>,)6(;/C [email protected],.5L .)6= +(*, ./ (/>,)6(;/ D E?, 0(=>;+5(/A ;> 6?, [email protected] [email protected];6,(/ [email protected](;/9 @,[email protected],=,/6= . )?./A, (/ 4?()? +,G,+3=9 ;> [email protected];6,(/ [email protected]<)6<@,Q KD [email protected]([email protected] S ',);/[email protected] SD TD E,@6([email protected] UD V<.6,@/[email protected] WD ',);/[email protected] ./5 6,@6([email protected]
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!"#$%#!$&&
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Biol 112 - Sept. 28 (C) - #$!$ Diseases and protein...

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