531952 - EPITHELIUM Dr. Paul W. L. Kwan Tufts University...

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EPITHELUM 1 Veterinary Histology EPITHELIUM Dr. Paul W. L. Kwan Tufts University School of Medicine Learning Objectives 1. Know the main characteristics of epithelium. 2. Understand the main functions of epithelium. 3. Be able to classify various epithelia based on their histology. 4. Understand epithelial polarity and surface specialization at various domains. 5. The major classes of cell adhesion molecules, the molecules involved and whether they are calcium-dependent or not. 6. The interactions of adhesion molecules with neighboring cells and with the stroma. 7. The structures that make up cell junctions and how they control the passage of materials across an epithelium. 8. Hemidesmosomes, structure and function. 9. Gap junctions, their makeup and how they work. 10. The composition of the basal lamina and how it is different from the basement membrane. 11. Difference between exocrine and endocrine glands. 12. Classification of exocrine epithelial glands. 13. The various types of secretion from epithelial glands and how these materials look in histological sections. 14. The difference modes of secretion and how this may affect the cells doing the secreting. 15. Definition and parenchyma and stroma. 16. The role of myoepithelial cells in epithelial glands. 17. Understand that epithelial cells are constantly being replaced. 18. Very significant numbers of tumors are of epithelial origin.
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EPITHELUM 2 Veterinary Histology 1. Main Characteristics of Epithelium An epithelium is a continuous sheet of connected cells that covers or lines a body surface (e.g. skin, intestine). Secretory glands (e.g. sweat, salivary, mammary) are derived from epithelium. An epithelium contains very little extracellular matrix. An epithelium sits on a basal lamina . Epithelium does not contain blood vessels. Nutrients reach the cells of the epithelium via diffusion from blood vessels outside the basal lamina. This feature places a limit to how thick an epithelium can be. 2. Main Functions of Epithelial Tissue Covering and ling of surfaces (eg. Skin) Absorption (eg. Intestine) Secretion (eg. Sweat glands) Sensation (eg. Neuroepithelium) Contractility (eg. Myoepithelial cells) Since epithelial cells cover all of the external and internal surfaces of the body, everything that enters or leaves the body must cross an epithelial barrier. 3. Classification of Epithelia Epithelia are classified based on the number of cell layers and the shape of the cells at the uppermost layer. Simple Epithelium --- Only one layer of cells, all of which are in contact with the basal lamina. Depending on the shape of the cells, simple epithelia can be further divided into: Simple squamous --- One layer of flat cells. Examples: flat endothelium lines most blood and lymphatic vessels. Simple cuboidal
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This note was uploaded on 01/16/2012 for the course BI 200 taught by Professor Potter during the Fall '11 term at Montgomery College.

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531952 - EPITHELIUM Dr. Paul W. L. Kwan Tufts University...

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