BOD-Dermatology

BOD-Dermatology - Dermatology Lecture List 1. Introduction...

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Unformatted text preview: Dermatology Lecture List 1. Introduction 2. Eczematous Dermatitis & Urticaria 3. Common Dermatologic Problems 4. Path of Inflammatory Skin Disease 5. Pathophysioogy of Non-Melanoma Skin Cancer 6. Blistering Disorders 7. Nevi and Malignant Melanoma 01: Introducing Definitions Primary Lesions Initial (and sometimes the only) manifestation of skin disorder Macule flat lesion, can be any shape, size, or color, cant palpate! Papule IJ Plaque raised lesion, any shape or color. 1 cm is the cutoff (papule is smaller) Nodule spherical-ish lesion from dermis or subQ fat. If large = tumor Wheal = hive round lesion results from edema in dermis Bulla IJ Vesicle blister. 1 cm is the cutoff (bulla is smaller) Pustule a bulla or vesicle filled with pus Secondary Lesions s in skin which are superimposed upon or occur subsequently to primary lesions Erosion all or part of epidermisi is lost. heals WITHOUT scarring (dermis not involved) Ulcer hole in skin: loss of full thickness of epidermis + part/all of dermis. heals WITH scarring Excoriation linear erosion from scratching Fissure crack/split in skin Scale thick stratum corneum Crust scab: dried stuff Atrophy thinning of skin. generalized: phsyiologic aging; or localized: stretch marks Lichenification thickening of skin. exxaggeration of normal skin markings, results from repeated rubbing or scratching Arrangement of Lesions Linear curved (just kidding) Annular ring-shaped Serpiginous wandering or twisting, like a snake Herpetiform tight clustering of lesions heaped on top of on another; taken from the fashionable style of paris herpes Dermatomal lesions in a dermatome: shingles! 02: Eczematous Dermatitis & Urticaria Atopic Dermatitis Definition Atopic Dermatitis (AD) = chronic pruritic inflammation of skin associated with allergy Eczema = often used synonymously with AD, but it technically means a specific reaction pattern of erythema, scaling, and vesicles; can have many causes acute: erythema, vesicles, edema, serous exudate chronic: lichenification, scale, hyperpigmentation Pathophysiology Complicated: involves T cells, Langerhans cells, Eos, keratinocytes, cytokines, IgE Type I HSR : IgE in most. IL-4 may play major role in causing IgE (IL-4 inhibits IFN- ) Immunology review: dependent on which cytokines are present, Th0 are driven towards Th1 (IL-12) or Th2 (IL4) IL-4 stimulate B cells to make IgE Aeroallergens : seasonal variation, + test to skin dust in most patients Hyperresponsive Langerhans cells and T cell activation Defective epidermal barrier: ceramides J penetration of irritants, allergens, and microbes S. aureus : up to 90% colonization; anti-staph antibiotics leads to rapid response Food : Specific food elimination (nuts, etc) may be useful with severe AD, but not much of a difference in mild/moderate cases....
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This note was uploaded on 01/16/2012 for the course BI 200 taught by Professor Potter during the Fall '11 term at Montgomery College.

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BOD-Dermatology - Dermatology Lecture List 1. Introduction...

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