BOD-GIBlock1 10.30.55 AM

BOD-GIBlock1 10.30.55 AM - GI Block I Lecture List 01...

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Unformatted text preview: GI Block I: Lecture List 01) Esophageal Disorders .......................................................... Nompleggi 02) Gastric Mucosal Injury.......................................................... Houghton 03) Pathology of GI Inflammatory Disorders ............................ Banner 04) Pathology of Upper GI Tumors ............................................ Ayata 05) Pathophysiology of Diarrhea & Malabsorption.................. Bhattacharya 06) Pathology of Diarrhea & Malabsorption.............................. Banner 07) Pathophysiology of IBD........................................................ Zawacki 08) Pathology of Intestinal Inflammatory Disease ................... Banner 09) GI Neoplasia............................................................................ Barnard 10) Pathology of Colon Polyps/Cancer.......................................... Ayata 01: Esophageal Disorders& GERD Normal Esophagus Anatomy Histology Stratified squamous epithelium Z-line: stratified squamous of esophagus change to glandular columnar of stomach mucous glands in upper glands & near EG junction basal layer of cells is source of new epithelial cells UES (Upper Esophageal Sphincter) Anatomy LES (Lower Esophageal Sphincter) Anatomy not a distinct anatomical structure 2-4 cm intraluminal high pressure zone Physiology has intrinsic tone LES relaxation caused by stimulation of inhibitory neurons release of NO, VIP agents that ↑ LES pressure possible therapeutics antacids cholinergic agonists metoclopramide hormones gastrin motilin bombesin pancreatic polypeptide agents that ↓ LES pressure possible therapeutics anticholinergics theophylline β agonists α agonists hormones secretin CCK VIP progesterone lifestyle interventions caffeine fatty meal smoking ethanol chocolate 01: Esophageal Disorders& GERD The act of swallowing higher brain center activates swallowing center in brainstem nucleus ambiguous, dorsal motor nucleus in medulla pharyngeal contraction and UES relaxation coordinated primary peristalsis food propelled along esophagus, but insufficient to transport food bolus all the way to stomach secondary paristalsis initiated when esophagus is distended by food bolus or gastric contents this peristaltic wave complete transport of food bolus into stomach Esophageal Swallowing Disorders Esophageal Symptoms Dysphagia = difficulty swallowing oropharyngeal dysphagia = difficulty initiating swallow or transferring food from mouth into esophagus. Can also experience nasopharyngeal regurgitation (comes out nose) or pulmonary aspiration. esophageal dysphagia = food gets stuck in esophagus after swallowing secondary to NM (motility) or obstrutive (structural) disorder NM disorder Æ dysphagia to both solids and liquids Structural disorder Æ dysphagia to just solids (but may progress to liquid dysphagia too) Causes of dysphagia obstruction tumor/abscess of oropharynx vertebral osteophyte impinging on esophagus Strictures Rings (Schatzki) and Webs Extrinsic compression (neoplasms or blood...
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This note was uploaded on 01/16/2012 for the course BI 200 taught by Professor Potter during the Fall '11 term at Montgomery College.

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BOD-GIBlock1 10.30.55 AM - GI Block I Lecture List 01...

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