BrillaV2 - Zinc-Magnesium Supplementation, Hormones and...

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Zinc-Magnesium Supplementation, Hormones and Strength JEP online Journal of Exercise Physiology online Official Journal of The American Society of Exercise Physiologists (ASEP) ISSN 1097-9751 An International Electronic Journal Volume 3 Number 4 October 2000 Exercise Nutrition Effects of a Novel Zinc-Magnesium Formulation on Hormones and Strength L.R. BRILLA 1 AND VICTOR CONTE 2 1 Exercise and Sports Science Laboratory, Western Washington University, Bellingham, WA 98225-9067 and 2 BALCO Laboratories, 1520 Gilbreth Road, Burlingame, CA 94010, Tel: 800-777-7122 L.R. BRILLA AND VICTOR CONTE. Effects of a Novel Zinc-Magnesium Formulation on Hormones and Strength . JEP online , 3(4): 26-36, 2000. Muscle attributes and selected blood hormones of football players were assessed in response to a nightly supplementation regimen during spring football, over an 8-week period, with pre-post measures. A double-blind randomized study was conducted with ZMA (30 mg zinc monomethionine aspartate, 450 mg magnesium aspartate, and 10.5 mg of vitamin B-6) and placebo (P), n=12 and n=15, respectively. Plasma zinc and magnesium levels were ZMA (0.80 to 1.04 μ g/ml ; 19.43 to 20.63 mcg/ml ) and P (0.84 to 0.80 μ g/ml ; 19.68 to 18.04 μ g/ml), respectively (P<0.001). Free testosterone increased with ZMA (132.1 to 176.3 pg/mL), compared to P (141.0 to 126.6 pg/mL) (P<0.001); IGF-I increased in the ZMA group (424.2 to 439.3 ng/mL) and decreased in P (437.3 to 343.3 ng/mL) (P<0.001). Muscle strength via torque measurements and functional power were assessed with a Biodex dynamometer. Differences were noted between the groups (P<0.001): ZMA (189.9 to 211 Nm at 180º/s and 316.5 to 373.7 Nm at 300º/s) and P (204.2 to 209.1 Nm at 180º/s and 369.5 to 404.3 Nm at 300º/s). The results demonstrate the efficacy of a Zn-Mg preparation (ZMA) on muscle attributes and selected hormones in strength-trained, competitive athletes. Key Words: vitamin B 6 , anabolic hormones, testosterone, IGF-I, muscle INTRODUCTION Zinc (Zn) and magnesium (Mg) may enhance levels of Insulin-like Growth Factor-I (IGF-I)(1); and zinc, in particular, may contribute to elevating serum testosterone (2). Both IGF-I and testosterone are anabolic factors that enhance muscle function and physical performance. Testosterone's role in physical performance enhancement has been studied for a number of years. The IGF-I response to intense muscular activity has not been well defined, relatively. Training may lead to a short-term catabolic state hormonally expressed by reductions in IGF-I. Baseline serum concentrations of testosterone, GH, and IGF-I were unaffected by 16-wk resistive training program which elicited an approximate 40% increase in muscular strength in men, 60 ± 4 yr. It was intimated that training-induced increases in IGF-I could occur in muscle without altering serum IGF-I concentration (3). A condition named somatopause due to decreased IGF-I and GH has been identified with aging. To countermeasure somatopause, 33 moderately obese women (67.1 ± 5.2 yr), self-injected IGF-I. Weight loss with muscle strength increases were greater in IGF-I group due to training (12-wk: walk 3 days,
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Zinc-Magnesium Supplementation, Hormones and Strength 27 strength trained 2 days) (4).
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BrillaV2 - Zinc-Magnesium Supplementation, Hormones and...

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