86 - Int J Oral Sci (2011) 3:180-191. www.ijos.org.cn...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Int J Oral Sci (2011) 3:180-191. www.ijos.org.cn REVIEW A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma Song Fan 1 †, Qiong-lan Tang 2 †, Ying-jin Lin 3 †, Wei-liang Chen 1 *, Jin-song Li 1 , Zhi-quan Huang 1 , Zhao-hui Yang 1 , You-yuan Wang 1 , Da-ming Zhang 1 , Hui-jing Wang 1 , Eduardo Dias-Ribeiro 4 , Qiang Cai 1 , Lei Wang 1 1 Department of Oral and Maxillofacial Surgery, Sun Yet-Sen Memorial Hospital (Second Affiliated Hospital) of Sun Yat-Sen University, Guangzhou 510120, China 2 Department of Pathology, Sun Yet-Sen Memorial Hospital (Second Affiliated Hospital) of Sun Yat-Sen University, Guangzhou 510120, China 3 Department of Neurology, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China 4 Faculty of Dentistry, University Center of João Pessoa, João Pessoa 1602, Brazil Oral squamous cell carcinoma (OSCC) has a high incidence of cervical micrometastases and sometimes metastasizes contralaterally because of the rich lymphatic intercommunications relative to submucosal plexus of oral cavity that freely communicate across the midline, and it can facilitate the spread of neoplastic cells to any area of the neck consequently. Clinical and histopathologic factors continue to provide predictive information to contralateral neck metastases (CLNM) in OSCC, which determine prophylactic and adjuvant treatments for an individual patient. This review describes the predictive value of clinical-histopathologic factors, which relate to primary tumor and cervical lymph nodes, and surgical dissection and adjuvant treatments. In addition, the indications for elective contralateral neck dissection and adjuvant radiotherapy (aRT) and strategies for follow-up are offered, which is strongly focused by clinicians to prevent later CLNM and poor prognosis subsequently. Keywords : oral squamous cell carcinoma; lymph node metastasis; contralateral neck metastasis; neck dissection; head and neck cancer International Journal of Oral Science (2011) 3 : 180-191. doi: 10.4248/IJOS11068 Introduction Oral squamous cell carcinoma (OSCC) is the most frequent of head and neck malignancies, which repre- sents approximately 3% of all malignancies in the body and accounts for more than five hundred thousand newly diagnosed cancers every year worldwide. Several studies have been concerned on the cervical metastases and †These authors contributed equally to this work. *Correspondence: Wei-liang Chen Tel: 86 20 81332429; Fax: 86 20 81332853 E-mail: [email protected] Received 14 March 2011; Accepted 23 August 2011 prognosis of OSCC. Recently, more retrospective studies have analysed some clinical-histopathologic prognostic- cators influencing contralateral neck metastases (CLNM) in OSCC. OSCC has a high incidence of cervical micro- metastases and sometimes metastasis contralaterally be- cause of the rich lymphatic intercommunications relative to submucosal plexus of oral cavity that freely commu-
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 01/16/2012 for the course BI 200 taught by Professor Potter during the Fall '11 term at Montgomery College.

Page1 / 12

86 - Int J Oral Sci (2011) 3:180-191. www.ijos.org.cn...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online