CellBiologyLab

CellBiologyLab - School of Anatomy - Cell Biology Lab Dr...

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Dr Mark A. Hill Phone: +612 9385-2477 or 2474 Fax: +612 9313-6252 Postal Address Email : m.hill@unsw.edu.au Room G20 Wallace Wurth Building Back to Research Labs page Download acrobat PDF version of this page- cblpage.pdf (120kb) | more information? Pick the Topic of Interest Research Teaching Adminstration or Visit the Lab Tissue Culture Primary Tissue Culture Research Background Publications Collaborations Research Methods WWW Research Links Visit the Lab Journal Roundup Libraries Search Honours Projects top of page By Topic Actin Apoptosis Cytoskeleton Fragile X Glaucoma mRNA Localization Neurons Retina Papers Background M ulticellular organisms generate many different cell shapes (see the neuron shown at the top of this page) using the actin cell cytoskeleton. If the actin filaments are essentially the same in all cells, how are different shapes generated? The specific aim is to elucidate the role of the actin cytoskeleton in altering the shape of a neuron as it differentiates from an immature round cell into a complex cell shape: a cell body with long polarised processes. O ur lab has described how the positioning within the cell of protein translation, that is, intracellular messenger RNA localization, may regulate the cell cytoskeleton. Just think of the possibilities for other biological systems and tissues. ( More? mRNA Localization ). For example, in humans the most abundant mental retardation disease is Fragile X Syndrome. The protein involved with this disease is an RNA binding protein whose function in neurons has yet to be determined ( More? Fragile X ) . School of Anatomy - Cell Biology Lab http://anatomy.med.unsw.edu.au/cbl/ (1 of 8) [1/6/2000 5:12:23 PM]
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Meetings Research Background I t has been shown that localization of messenger RNA within the egg is critical in determining embryo polarity. We are suggesting that such a fundamental mechanism in the embryo is also utilized in somatic cells to regulate the cell cytoskeleton and will possibly be involved in cell plasticity/polarity. To this end the Lab is currently focused upon the development of neurons ( More? Neurons ) . In particular the lab is investigating actin mRNA, protein and microfilament localization ( More? Cytoskeleton ) . T he cell cytoskeleton regulates both cell shape and cell motility. By regulating signalling in neurons and identifying specific cytoskeletal proteins, we can also look at the relationship between these 2 programs. These finding have applications not only to our understanding of Cell Biology, but also potential applications to many disease processes. The current area of neuronal disease interest is in glaucoma ( More? Glaucoma ), where we are looking at the relationship between increased pressure and neuronal cell death. ( More? ORIA Grant-Glaucoma ). We currently have a PhD scholarship available beginning year 2000 in this area of research please contact Dr Mark Hill. More Information
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CellBiologyLab - School of Anatomy - Cell Biology Lab Dr...

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