Hypersenstivitylecturehandout - HYPERSENSITIVITY REACTIONS...

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1 HYPERSENSITIVITY REACTIONS AND IMMUNITY DISORDERS (Chapter 16/17) Hypersensitivity or an _________________ reaction is an _____________________ response by the immune system to a __________________ causing damage to the host. An ______________ is a substance that acts as an ________________ in a hypersensitive individual which is normally ________________. Isoantigens are antigens which vary in the same ____________. Autoimmunity is an abnormal immune response to ________ antigens. Tolerance is the body's ability to suppress an immune response to "self" antigens ( autoantigens ) – it occurs during fetal development. If a fetus is exposed to an antigen during development, the matching antibodies/sensitized T-cells are deleted before & after birth. Loss of tolerance may occur through mutation, stimulation by pathogens (mimicry) or other unknown causes at any time during life causing autoimmune diseases. Portals of entry for allergens include _________________ (eg pollen) __________________ (eg peanuts) ________________ (eg bee sting) and _________________ (eg cosmetics). see Table 16.2. 4 Main Hypersensitivity Reactions Mediated by Type 1 Atopic allergy (localized anaphylaxis & systemic anaphylaxis) _____, ___________, _________________ Type 2 Cytotoxic Reactions _____________________, ______, & ____ Type 3 Immune Complex Reactions _____________________, ______, & ____ Type 4 Delayed Hypersensitivity Reactions (Cell-Mediated) ______, ____________________________ Type 1 Atopy/Anaphylaxis (Figures 16.3, 16.4) Causes ; _____________, ________________, ________________, ________________, ____________ ,_____________, ________________, ________________, ________________, During sensitization, a person encounters the allergen for the first time (often unknowingly, hidden in foods or in utero) producing _____________ cells which release _______. This antibody has an _______ region which has a great affinity for __________ and _____________ but no symptoms appear - this is referred to as the ________________ dose. The IgE-primed mast cells may remain unchallenged for ___________ until the person encounters the allergen for the second time which is known as the _________________ dose. The allergen binds to the sensitized cells which stimulates the mast cell to _____________________ & release __________________. There are ______ chemical mediators which can be released including __________________, _____________________, ___________________ etc. These chemical mediators swiftly produce the allergic reaction by diffusing into the _______________ and bloodstream triggering numerous physiological effects on target organs. Examples of atopic allergies include ___________, ___________________, ______________. What is
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This note was uploaded on 01/16/2012 for the course MICROBIO 1 taught by Professor Drelisabeththompson-eagle during the Summer '11 term at Riverside Community College.

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Hypersenstivitylecturehandout - HYPERSENSITIVITY REACTIONS...

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