251 antibiotics - Penicillins Figure 20.6 Penicillinase Figure 20.8 Monobactam(aztreonam • Cephalosporins • 2 nd 3 rd and 4 th generations more

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Chapter 20 Antimicrobial Drugs
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History of Antibiotics 1495 Europeans used mercury to treat Syphilis 1630 Europeans used Quinine to threat malaria 1908 Gelmo synthesized first sulfa drug 1908-10 Ehrlich nobel prize for “606” (salvarsan) used to treat syphilis 1924 Gratia and Dath systematic search of soil microbes - discovered actinomycetin 1928 Fleming - penicillin 1935 Domagk developed prontosil 1945 - >5488 sulfonamides 1944/5 Waksman --> identified streptomycin 1945 Flemming Florey & Chain nobel prize penicillin
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Ehrlich
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Flemming Florey
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1928 – Fleming discovered penicillin, produced by Penicillium . 1940 – Howard Florey and Ernst Chain performed first clinical trials of penicillin. Figure 20.1
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Waksman Domagk
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Table 20.1
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Table 20.2
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The Action of Antimicrobial Drugs Figure 20.2
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The Action of Antimicrobial Drugs Figure 20.4
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Unformatted text preview: Penicillins Figure 20.6 Penicillinase Figure 20.8 Monobactam (aztreonam) • Cephalosporins • 2 nd , 3 rd , and 4 th generations more effective against gram-negatives Antibacterial Antibiotics Inhibitors of Cell Wall Synthesis Figure 20.9 Bacitracin Vancamycin Isoniazid & Ethambutol Neomycin, Gentamycin, streptomycin Erythromycin Polymyxin B Quinolones • Sulfonamides (Sulfa drugs) • Inhibit folic acid synthesis • Broad spectrum Antibacterial Antibiotics Competitive Inhibitors Figure 5.7 Sulfanamide Figure 20.13 Amphotericin B Myconazole Antiviral Drugs Nucleoside and Nucleotide Analogs Figure 20.16a Antiviral Drugs Nucleoside and Nucleotide Analogs Figure 20.16b, c Disk-Diffusion Test Figure 20.17 Broth Dilution Test Figure 20.19 Effects of Combinations of Drugs Figure 20.22...
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This note was uploaded on 01/16/2012 for the course BIOLOGY 251 taught by Professor Lancebowen during the Fall '10 term at Truckee Meadows Community College.

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251 antibiotics - Penicillins Figure 20.6 Penicillinase Figure 20.8 Monobactam(aztreonam • Cephalosporins • 2 nd 3 rd and 4 th generations more

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