Pathology - Chapter 15 Microbial Mechanisms of Pathogenicity Microbial Mechanisms of Pathogenicity Pathogenicity The ability to cause disease

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Chapter 15 Microbial Mechanisms of Pathogenicity
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Microbial Mechanisms of Pathogenicity Pathogenicity The ability to cause disease Virulence The extent of pathogenicity
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Mucous membranes Skin Parenteral route Portals of Entry
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ID 50 : Infectious dose for 50% of the test population LD 50 : Lethal dose (of a toxin) for 50% of the test population Numbers of Invading Microbes
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Bacillus anthracis Portal of entry ID 50 Skin 10-50 endospores Inhalation 10,000-20,000 endospores Ingestion 250,000-1,000,000 endospores
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Adhesions/ligands bind to receptors on host cells Glycocalyx Streptococcus mutans Fimbriae Escherichia coli M protein Streptococcus pyogenes Opa protein Neisseria gonorrhoeae Tapered end Treponema pallidum Adherence
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Coagulase Coagulate blood Kinases Digest fibrin clots Hyaluronidase Hydrolyses hyaluronic acid Collagenase Hydrolyzes collagen IgA proteases Destroy IgA antibodies Siderophores Take iron from host iron- binding proteins Antigenic variation Alter surface proteins Enzymes
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Penetration into the Host Cell Figure 15.2
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This note was uploaded on 01/16/2012 for the course BIOLOGY 251 taught by Professor Lancebowen during the Fall '10 term at Truckee Meadows Community College.

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Pathology - Chapter 15 Microbial Mechanisms of Pathogenicity Microbial Mechanisms of Pathogenicity Pathogenicity The ability to cause disease

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