Lecture6 - Lecture 6 10/5/11 Outline: Secondary structure...

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Lecture 6 10/5/11 Outline: ± Secondary structure of proteins. ± X-ray crystallography. ± Peptide backbone. ± α -Helix. ± Random coil. ± β -Sheet.
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± Secondary Structure of proteins (II o Structure) Secondary structure of a protein refers to the conformation of the peptide backbone. O C R 1 H 3 N + C H COO - R 2 N C H H Have already seen how amino acids are linked together by covalent peptide bonds. Resonance confers stability to this bond. C-N has some double bond character and thus has some rigidity and cannot rotate freely. O C N H O - C N + H
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X-ray crystallography Means of studying protein conformation by determining the position of atoms in space. Study angles and intensities at which X-rays of a given wavelength are scattered or diffracted by electrons that surround each atom. Highest densities give greatest diffraction of X-rays. X-ray diffraction pattern If the sample is a well-ordered crystal, at certain points the waves reinforce one another and appear as diffraction spots on a detector. The diffraction pattern, combined with the amino acid composition, can be used
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Lecture6 - Lecture 6 10/5/11 Outline: Secondary structure...

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