Lecture7 - Lecture 7 10/7/11 Background reading: Berg, et...

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Unformatted text preview: Lecture 7 10/7/11 Background reading: Berg, et al: pages 45 50, 62 Garrett and Grisham: p ages 106 - 112 Outline Secondary Structure of Proteins (continued). Random coil. Sheet. Ribbon models of proteins. Tertiary structure of proteins (III o structure). Bonds involved in stabilization of tertiary structure. Protein denaturation. Renaturation of proteins. Dialysis. The primary structure of a protein determines its tertiary structure. Secondary structure of proteins (continued) In previous lecture we had considered the -helix as a form of II structure. Random coil The term, random coil, refers to a flexible, changing, statistically random structure. The backbone of polylysine would have a random coil structure at pH 7. Sheet Two types: Antiparallel Parallel Get hydrogen bonding between the strands. All peptide linkages participate. The R groups alternately project above and below the plane of the sheet. Often called pleated sheet. Ribbon models of proteins Ribbon models are often used to demonstrate the secondary structure characteristics of particular proteins. A protein composed of a mixture of helices and parallel sheets....
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Lecture7 - Lecture 7 10/7/11 Background reading: Berg, et...

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