FA2011lecture6

FA2011lecture6 - Generic view of eukaryotic gene structure...

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Unformatted text preview: Generic view of eukaryotic gene structure coding region Silencer/ Silencer/ (upstream) regulatory region RNA interference (RNAi): a newly recognized mode of gene regulation dsRNA (21-24 nt) Mechanism still a very active area of investigation Expression of many genes regulated by this mechanism May be important for defense against viral infection VERY USEFUL TOOL FOR GENETICISTS! Also very promising avenue for treatment of diseases caused by gene misregulation, e.g. cancer (21-24 nucleotides long) RNAi: short double- stranded RNA molecules block gene expression via multiple mechanisms Current model for alternate mechanisms of small RNA +RISC-mediated downregulation of gene expression complementary mRNA is degraded translation of complementary mRNA is inhibited mutation: change in a gene that alters or impairs its function (germline/germinal mutations passed from parents to offspring, somatic are not) mutant allele: altered version of a gene whose function has been...
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FA2011lecture6 - Generic view of eukaryotic gene structure...

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