FA2011lecture9

FA2011lecture9 - Hallmark: most if not all affected...

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karyotype of a human male
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Females have two copies of every gene on X while males have only one… dosage compensation or X- inactivation mechanisms ensure similar amounts of X-linked gene product in males and females
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Calico coloration in cats is due to X-inactivation (females heterozygous for black and orange alleles of a fur color gene – orange allele inactivated in about half the cat ` s cells, black in the other half)
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Unformatted text preview: Hallmark: most if not all affected individuals are males (although this by itself does not necessarily mean trait is X-linked have to analyze whole pedigree!) Pedigree for red-green colorblind trait in a human family (X-linked recessive trait): (vitamin D-resistant rickets) Hallmark: female can pass on to both daughters and sons; male pass on to all daughters and no sons!...
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FA2011lecture9 - Hallmark: most if not all affected...

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