FA2011lecture10

FA2011lecture10 - Retinoblastoma: variable expressivity and...

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incomplete penetrance: some individuals who have the mutant genotype do not show the mutant phenotype percent penetrance = # individuals who show mutant phenotype/ # individuals who must have mutant genotype
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Variable expressivity: Piebald spotting patterns conferred by same dominant S p allele in beagles
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Unformatted text preview: Retinoblastoma: variable expressivity and incomplete penetrance unaffected unilateral bilateral Acts as autosomal dominant with 75% penetrance (in this pedigree, 4/5 = 80%) Reasons for variable expressivity/ incomplete penetrance: • Chance • Environmental influences • Genetic background...
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This note was uploaded on 01/16/2012 for the course BICD 100 taught by Professor Nehring during the Fall '08 term at UCSD.

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FA2011lecture10 - Retinoblastoma: variable expressivity and...

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