FA2011lecture16

FA2011lecture16 - Also known as: l BAC by BAC approach z...

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Unformatted text preview: Also known as: l BAC by BAC approach z Fragments ~500kb (if no overlap, would need 6,000 pieces of this size to cover the entire human genome) Called a l physical map z This is a l contig z Red stars identify a l minimum tiling path l whole genome shotgun sequencing z Advantage: less work Disadvantage: more gaps in fnal assembly published in Wed. Oct. 27 2010 issue of Nature Positional cloning: general strategy If < 1 cM apart average of 12 candidate genes (1989) Identification of human disease genes: what is it good for? Gene therapy: introduce functional copy of gene into cells that need it (only relevant if disease caused by loss of function mutation) highly problematic approach! Provides a definitive for diagnosis (affected individuals, carriers) Allows creation of animal model of disease to use for experiments testing new therapies Better understanding of disease and mutations causing it leads to new ideas for treatment Cystic fbrosis (CF) is a atal genetic disease caused by mutations in...
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FA2011lecture16 - Also known as: l BAC by BAC approach z...

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