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FA2011lecture23

FA2011lecture23 - Quantitative trait no discrete phenotypic...

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Quantitative trait: no discrete phenotypic categories but instead a continuum, typically controlled by multiple genes as well as by environment Complex trait: trait (which may be quantitative or all-or-none) whose genetic control is obscured by one or more confounding factors such as multigenic control, incomplete penetrance, more than one gene that can mutate to give same phenotype, trait may be “phenocopied” in a non- heritable way… exempliFed by breast cancer
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the blue haplotype is in l linkage disequilibrium z with the disease mutation l HAPLOTYPE ASSOCIATION z AKA l GENOME-WIDE ASSOCIATION z EMPLOY SIMILAR LOGIC ALREADY DISCUSSED FOR QTL MAPPING TO MAP GENES AFFECTING COMPLEX TRAITS THAT ARE DIFFICULT OR IMPOSSIBLE TO MAP USING CONVENTIONAL LINKAGE ANALYSIS Essentially, this type of analysis tests whether a particular haplotype occurs more frequently within a group of unrelated individuals exhibiting a particular trait than those without the trait.
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FA2011lecture23 - Quantitative trait no discrete phenotypic...

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