FA2011lecture25

FA2011lecture25

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Unformatted text preview: nction). Gain of function mutations can cause phenotypes that don’t reflect wild type function of gene! Loss of function mutations (ideally null alleles) are the most informative. WT Antp gene expressed predominantly in T2: antp homozygous null phenotype: legs on T2 second thoracic segment develop as antennae… conclusion: WT Antp gene required for proper specification of T2 identity Drosophila homeobox genes organized into two unlinked complexes: Antp and Bx: The arrangement of homeobox genes in these clusters mirrors their patterns of expression and function along the anterior-posterior axis: Encode transcription factors that regulate the expression of many other genes model for evolution of homeobox gene clusters: Homeobox gene clusters are found in all metazoans; apparently formed via sequential, tandem duplication followed by functional divergence Do they play the same role in development in all these organisms? Hox gene clusters and expression patterns in mice: Does misexpression of Hox genes alter segment identities in the mouse?! Introduce transgene with HoxA1 regulatory region driving HoxD4 expression: result: occipital bones transformed to cervical-like bones with characteristic arches...
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This note was uploaded on 01/16/2012 for the course BICD 100 taught by Professor Nehring during the Fall '08 term at UCSD.

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