Lecture 5 - Hemoglobin - Principles of ligand binding and...

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Unformatted text preview: Principles of ligand binding and cooperativity Myoglobin and Hemoglobin Oxygen Carriers in Mammals Stryer: 7.1-7.4 1 Myoglobin is the simplest oxygen binding protein Single polypeptide (153 aa), mostly -helix Myoglobin (Mb) 2 Myoglobin (Mb) is the simplest oxygen binding protein and is found abundantly in muscle Hemoglobin (Hb) is the O 2 carrier in blood Each red blood cell (erythrocyte) carries 3 x 10 8 molecules of Hb (34% of cell is Hb) One mL of blood: 5 x 10 9 erythrocytes Hb delivers the O 2 and Mb retrieves the O 2 from Hb and stores it in muscles for future use Myoglobin and Hemoglobin - Oxygen Carriers in Mammals 3 Red Blood Cells 4 Need to deliver O 2 from lungs to all parts of body via bloodstream O 2 is only soluble to ~ 200 M in blood Hb is soluble to ~10 mM - 50-fold greater Blood can also return CO 2 generated from metabolism back to the lungs Mb is found in muscle where it takes O 2 from Hb to use for energy Why do we need Hemoglobin as an O 2 Carrier in Blood?...
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Lecture 5 - Hemoglobin - Principles of ligand binding and...

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