Lecture 10 Glycolysis - Glycolysis Chapter 16.1-16.2 The...

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Glycolysis Chapter 16.1-16.2 The first stages of metabolizing sugars anaerobically TCA Cycle 1
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2
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Anaerobic and Aerobic Metabolism of Glucose 3
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It is common to almost all organisms The Glycolytic pathway splits a six carbon sugar into two 3-carbon compounds in three stages 4
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The First Stage of Glycolysis 5
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Stage 1 6
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Hexokinase uses Induced Fit 8 Å 7
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Hexokinase Uses an Induced Fit E + Glucose ES Voet and Voet, Wiley 8
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Preparing for the split I somerase 9
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Aldolase is the enzyme that cleaves the critical bond 10
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R O R + R-NH 3 R N H R R H 2 O Schiff Base See pg 606 (582) for details Aldolase reaction - retroaldol condensation 11
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Triose phosphate isomerase interconverts dihydroxyacetone phosphate and glyceraldehyde 3- phosphate Two molecules of glyceraldehyde 3-phosphate can now enter Stage 3 of glycolysis – only one path to finish Stage 2: Isomerization of Dihydroxyacetone phosphate to glyceraldehyde 3-phosphate 12
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II III 13
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TIM-barrel α,β- Barrel Very stable and common k cat /K m = 2 x 10 8 M -1 s -1 !!! 14
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Lecture 10 Glycolysis - Glycolysis Chapter 16.1-16.2 The...

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