Lecture 10 Metabolism - Metabolism Basic Concepts and...

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Metabolism Basic Concepts and Design 1
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Questions we will address in the next few weeks Catabolism: How does a cell extract energy and reducing power from its environment? Anabolism: How does a cell synthesize the building blocks of its macromolecules and then the macromolecules themselves? 2
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Metabolism and Glycolysis Chapter 15.1-15.4 Metabolism is composed of many coupled reactions ATP is used as an energy currency Oxidation of carbon fuels produces energy Metabolic pathways contain many recurring motifs and chemical reactions 3
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Reaction/Pathway Requirements: 1. Specificity 2. Thermodynamically favored Catabolism and Anabolism often occur in distinct parts of the cell Glucose Metabolism 4
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G of chemically coupled reactions is the sum of the changes of the individual reactions A <=> B + C Gº = +5 kcal/mol B <=> D Gº = -8 kcal/mol ____________________________ A <=> C + D Gº = -3 kcal/mol
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Can We Couple ATP hydrolysis to unfavorable reactions? ATP + H2O ADP + Pi Gº = -7.3 kcal/mol A + B  C+D Gº = + 4 kcal/mol A + B + ATP  C + D + ADP + Pi Gº = -3.3 kcal/mol Is this coupled? Is this magic? This reaction is not coupled, so it will not occur with favorable Gº, although the hydrolysis of ATP can occur 6
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A Coupled Reaction Scheme A + ATP <=> A-P + ADP A-P + B <=> A-B + Pi _____________________ A + B + ATP <=> A-B + ADP + Pi
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This note was uploaded on 01/16/2012 for the course BIOLCHEM 415 taught by Professor Michaeluhler during the Fall '06 term at University of Michigan.

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Lecture 10 Metabolism - Metabolism Basic Concepts and...

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