Lecture 11 TCA - Metabolism II: Aerobic respiration...

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Metabolism II: Aerobic respiration Tricarboxylic Acid (TCA) Cycle - also known as the Citric Acid Cycle or the Krebs Cycle Occurs in the mitochondrion and is central to aerobic respiration and other metabolic pathways Among other metabolites, the TCA cycle utilizes pyruvate produced in glycolysis Breakdown glucose (6C): (2x) Pyruvate (3C) (2x) ATP 2 NADH
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Cellular Respiration Each 2C fragment (acetylCoA) oxidized to H Each 2C fragment (acetylCoA) oxidized to H 2 O + CO O + CO 2 2 gives gives ~11 molecules of ATP + 1 GTP (~ ~11 molecules of ATP + 1 GTP (~ 12 ATP equivalents 12 ATP equivalents ) 1 Glucose: 2 ATP (glycolysis), ~28 ATP equiv (TCA/Oxidative phos.) 1 Glucose: 2 ATP (glycolysis), ~28 ATP equiv (TCA/Oxidative phos.)
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Krebs (TCA) Cycle
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Mitochondria Cristae
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Cutaway View of Mitochondrion
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Converting Pyruvate to Acetyl CoA S O H 3 C CoA This reaction is catalyzed by the pyruvate dehydrogenase complex .
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+ ==> acetyl CoA + CO 2 + NADH + H + Coenzyme A S O H 3 C CoA Pyruvate Dehydrogenase Complex
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This note was uploaded on 01/16/2012 for the course BIOLCHEM 415 taught by Professor Michaeluhler during the Fall '06 term at University of Michigan.

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Lecture 11 TCA - Metabolism II: Aerobic respiration...

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