Lecture 13 PPP - The Pentose Phosphate Pathway Chapter...

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operates in all organisms generates NADPH for synthetic and reductive reactions generates sugars used in other pathways (C 4 , C 5 , C 7 ) Direct connection to glycolysis and gluconeogenesis Chapter 20.3-20.5 aka Hexose Monophosphate Pathway aka Phosphogluconate Pathway aka Pentose Shunt The Pentose Phosphate Pathway
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Major Pathways Requiring NADPH
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Tissues with a highly active pentose phosphate pathway Liver and adipose tissue are the most significant
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It is common to almost all organisms The Glycolytic pathway splits a six carbon sugar into two 3-carbon compounds
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Another use for glucose 6-phosphate is the pentose phosphate pathway (Chapter 20) + CO 2
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Generation of NADPH Interconversion of carbohydrates PPP Overview
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Two oxidative steps convert glucose 6-P to ribulose 5-P and yield 2 NADPH oxidative decarboxylation ? C OH O OH H OH H CH 2 OPO 3 3-Keto-6-phospho-gluconate H O Remember
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Glucose 6-phosphate + 2 NADP + + H 2 O ==> ribose 5-phosphate + 2 NADPH + 2H + + CO 2 R = H in NAD + R = PO 3 2- in NADP + NADP +
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Interconversions of Pentoses C H O C C CH 2 OPO 3 OH H OH H OH H Ribose-5-P C C C CH 2 OPO 3 OH H OH H Ribulose-5-P O CH 2 OH C C C CH 2 OPO 3 H HO OH H Xyulose-5-P O CH 2 OH Phosphopentose Isomerase Phosphopentose Epimerase
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Interconversions of Pentoses C H O C C CH 2 OPO 3 OH H OH H OH H Ribose-5-P C C C CH 2 OPO 3 OH H OH H Ribulose-5-P O CH 2 OH C C C CH 2 OPO 3 H HO OH H Xyulose-5-P O CH 2 OH Phosphopentose Isomerase Phosphopentose Epimerase C C C CH 2 OPO 3 OH H OH H HO CH
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This note was uploaded on 01/16/2012 for the course BIOLCHEM 415 taught by Professor Michaeluhler during the Fall '06 term at University of Michigan.

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Lecture 13 PPP - The Pentose Phosphate Pathway Chapter...

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