Lecture 9 Signaling - Biochemistry Sixth Edition Chapter 14:

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Unformatted text preview: Biochemistry Sixth Edition Chapter 14: Signal-Transduction Pathways Copyright 2007 by W. H. Freeman and Company Berg Tymoczko Stryer Three signal transduction pathways Principles of signal transduction Release of the primary messenger Reception Interaction of the primary messenger with receptors Relay of the signal: generation of second messengers activation of protein kinase cascades Response Activation or inhibition of effector proteins that directly alter the physiological response Signal termination Specificity/selectivity Affinity Second messengers Characteristics : Intracellular mcls Concentration changes in response to signaling events Signal amplification Signaling: seven transmembrane helix receptors and heterotrimeric G proteins hormones, neurotransmitters odorants photons Approx. 33% of therapeutic drugs target receptors of this class Structure of 7TM receptors Pass through the membrane 7 times Also called serpentine receptors Rhodopsin : 7TM receptor plays an essential role in vision first member of the family to a structure determined Ligand binding to 7TM receptors leads to activation of heterotrimeric G proteins G protein: binds guanine nucleotides Also, hetero tri meric G-protein: , and subunits G ACTIVE 7TM receptors = G-protein coupled receptors (GPCRs) The surface of G that binds also binds adenylate cyclase = G proteins transmit a signal when bound to GTP and are silent when bound to GDP...
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This note was uploaded on 01/16/2012 for the course BIOLCHEM 415 taught by Professor Michaeluhler during the Fall '06 term at University of Michigan.

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Lecture 9 Signaling - Biochemistry Sixth Edition Chapter 14:

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