Cpt 5 PP slides revised

Cpt 5 PP slides revised - Chapter5 Stereochemistry...

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Created by Ch. 5 - 1 Chapter 5 Stereochemistry Chiral Molecules
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About The Authors These Powerpoint Lecture Slides were created and prepared by Professor  William Tam and his wife Dr. Phillis Chang.   Professor William Tam received his B.Sc. at the University of Hong Kong in  1990 and his Ph.D. at the University of Toronto (Canada) in 1995.  He was an  NSERC postdoctoral fellow at the Imperial College (UK) and at Harvard University  (USA).  He joined the Department of Chemistry at the University of Guelph  (Ontario, Canada) in 1998 and is currently a Full Professor and Associate Chair in  the department.  Professor Tam has received several awards in research and  teaching, and according to  Essential Science Indicators , he is currently ranked as  the Top 1% most cited Chemists worldwide.  He has published four books and over  80 scientific papers in top international journals such as  J. Am. Chem. Soc., Angew.  Chem., Org. Lett.,  and  J. Org. Chem.   Dr. Phillis Chang received her B.Sc. at New York University (USA) in 1994, her  M.Sc. and Ph.D. in 1997 and 2001 at the University of Guelph (Canada).  She lives  in Guelph with her husband, William, and their son, Matthew. Ch. 5 - 2
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Ch. 5 - 3 1. v An object is  achiral  (not chiral) if the object and its mirror image are identical
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Ch. 5 - 4 v chiral  object is one that cannot be superposed on its mirror image
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Ch. 5 - 5 v 66% of all drugs in development are  chiral , 51% are being studied as a  single  enantiomer v Of the $475 billion in world-wide sales of  formulated pharmaceutical products in  2008, $205 billion was attributable to  single enantiomer drugs
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Ch. 5 - 6 v Examples and Butane 2-Methylpropane Molecular Formula Cl Cl and 1-Chloro propane 2-Chloro propane Constitutional Isomers C4H10 C3H7Cl
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Ch. 5 - 7 v Examples Molecular Formula and Butan oic acid Methyl  propan oate OH O CH 3 O O Constitutional Isomers C2H6O C4H8O2 OH CH 3 O CH 3 and Ethan ol Methoxy methane
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Ch. 5 - 8 2B. Stereoisomers v Stereoisomers are  NOT  constitutional isomers v Stereoisomers  have their atoms connected in the same sequence but they  differ in the arrangement of their atoms in space.  The consideration of such  spatial aspects of molecular structure is called  stereochemistry
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Ch. 5 - 9 2C. v Stereoisomers can be subdivided into two general categories: enantiomers diasteromers Enantiomers  – stereoisomers whose molecules are nonsuperposable  mirror images of each other Diastereomers  – stereoisomers whose molecules are not mirror images  of each other
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Ch. 5 - 10 Subdivision of Isomers
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Ch. 5 - 11
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This note was uploaded on 01/16/2012 for the course PSYCH 373 taught by Professor Marthafaircloth during the Spring '09 term at Campbell.

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Cpt 5 PP slides revised - Chapter5 Stereochemistry...

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