Polioencephalomalacia

Polioencephalomalacia - Polioencephalomalacia (PEM) By:...

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Polioencephalomalacia (PEM) By: Juan Morales
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Pathology Literally means softening of the cerebral cortical grey matter of the brain. Disease characterized by a disturbance in the central nervous system. Brain of the infected animal becomes inflamed and swollen, and eventually becomes necrotic.
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Pathology cont’d Diagnosis is usually done by performing a necropsy on the brain of the dead animal. Dead grey matter will fluoresce under a wood’s lamp.
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Causes PEM sometimes occurs on high grain diets, and diets that include plants high on thiaminases and sulfur. Thiaminases are enzymes found in a few plants, such as bracken fern. When ingested these enzymes split thiamin (Vitamin B1), an important compound in energy metabolism, and render it inactive.
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Causes cont’d Normally ruminants are fairly resistant to thiamin deficiency since rumen microbes provide the animal with sufficient amounts of thiamin. However, the ingestion of thiaminases will
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This note was uploaded on 01/16/2012 for the course ANSCI 313 taught by Professor Dr.allanmorgan during the Fall '11 term at Tarleton.

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Polioencephalomalacia - Polioencephalomalacia (PEM) By:...

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