BSC 2010L Critical thinking 3

BSC 2010L Critical thinking 3 - Although mitochondrial...

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Critical Thinking 3 MELAS (Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes) is a progressive mitochondrial disease. It causes multiple organ systems problems including the cardiac muscle, skeletal muscle, central nervous system, and gastrointestinal system. Symptoms of MELAS involve brain dysfunction with seizures and headaches, as well as muscle disease, temporary local paralysis (stroke), and abnormal thinking. MT-ND1 and MT-ND5 genes make proteins for mitochondrial function, which helps convert oxygen and sugars to energy. MELAS is caused by mutations in this kind of genes in mitochondrial DNA. This mutation deforms the structure of mitochondria.
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Unformatted text preview: Although mitochondrial disorders may be caused by genetic mutation or inheritance from parents, byproducts of numerous reactions can accumulate in the cells and interfere with other chemical reactions. After all, it could damage to the mitochondria. Cellular respiration takes place in mitochondria. Moreover, ATP produced by mitochondria is essential for cell functions. In particular, ETC in inner membrane of mitochondria produces almost 90% of ATP in one cycle of cellular respiration. As a result, any defects of mitochondria could have pivotal effect on whole cellular respiration and even lead to the death of organism....
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